Healthcare AI Engineer

Insights on AI & Healthcare

Technical deep-dives on regulation, AI engineering, and bioinformatics for healthcare professionals.

3 min read

LLM Temperature: The One Parameter That Changes Everything

Temperature controls how an LLM picks its next word. A single number between 0 and 1 — and getting it wrong in a healthcare pipeline doesn't just produce mediocre output, it produces unpredictably wrong output.

LLMAI EngineeringHealthcare AIMachine Learning
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9 min readaudioavatar

The Invisible Filter That Decides Whether Healthcare AI Really Works

Why some systems shine in the lab and stumble in the hospital. A biostatistical principle has governed omics and clinical trials for three decades — and a personal reflection on whether it could become a validation standard for multi-agent AI workflows.

BiostatisticsClinical TrialsMulti-Agent AIBioinformaticsFDR
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7 min readaudioavatar

AI Doesn't Eliminate Technical Debt. It Multiplies It.

If you don't know what you're doing, AI lets you do it faster. That's it. That's the trap. Before, a mistake took hours to generate. Now it takes seconds.

AI StrategyTechnical DebtBest PracticesDecision-Making
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7 min readaudioavatar

Multi-Agent AI Systems in Clinical Research: Beyond the Single-Model Paradigm

A single LLM can't reliably manage a clinical trial. But a system of specialized agents — each with defined roles, validation gates, and failure protocols — can transform how we handle regulatory documents, patient data, and research coordination.

Multi-Agent AIClinical ResearchLLMArchitecture
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6 min read

Bioinformatics Pipeline Validation: ICC, Cohen's Kappa, and Spearman in Practice

A pipeline that runs without errors isn't a validated pipeline. Learn how inter-rater reliability metrics — ICC, Cohen's Kappa, and Spearman — separate reproducible science from expensive noise.

BioinformaticsValidationBiostatisticsReproducibility
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7 min read

Spec-Driven AI Development: Why Pharma Needs Formal Specifications Before Writing a Single Line of Code

Most AI projects in pharma fail not because of bad models, but because of unclear requirements. Spec-Driven Development forces you to define success before you build — reducing waste, accelerating validation, and making regulatory review predictable.

Spec-Driven DevelopmentPharmaAI EngineeringValidation
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8 min read

EU AI Act & Healthcare Software: What You Need to Know Before August 2026

The EU AI Act classifies most healthcare AI systems as high-risk. Here's what that means for your development roadmap, compliance budget, and go-to-market timeline.

EU AI ActHealthcareComplianceRegulation
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